Clinical and prognostic value of hTERT mRNA expression in patients with non-small-cell lung cancer | Zendy

Marzena Zalewska−Ziob | Zendy; Katarzyna Dobija-Kubica | Zendy; Krzysztof Biernacki | Zendy; Brygida Adamek | Zendy; Janusz Kasperczyk | Zendy; Krzysztof Bruliński | Zendy; Zofia Ostrowska | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Clinical and prognostic value of hTERT mRNA expression in patients with non-small-cell lung cancer

Author(s) -

Marzena Zalewska−Ziob,

Katarzyna Dobija-Kubica,

Krzysztof Biernacki,

Brygida Adamek,

Janusz Kasperczyk,

Krzysztof Bruliński,

Zofia Ostrowska

Publication year - 2017

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2017_1618

Subject(s) - telomerase reverse transcriptase , telomerase , lung cancer , grading (engineering) , carcinogenesis , adenocarcinoma , medicine , carcinoma , pathology , cancer research , clinical significance , lung , neoplasm , reverse transcription polymerase chain reaction , oncology , cancer , biology , gene expression , gene , ecology , biochemistry

Telomerase, undetectable in normal somatic cells, plays a critical role in carcinogenesis of the majority of human tumors including lung carcinoma. The aim of our study was to determine human telomerase reverse transcriptase (hTERT) mRNA expression in patients with non-small cell lung cancer (NSCLC) in order to estimate its usefulness as diagnostic and/or prognostic factor. hTERT expression was analyzed in a group of 12 females and 28 males with NSCLC using Quantitative Real-Time Polymerase Chain Reaction (QRT-PCR method) in cancerous and non-cancerous lung tissues. Results were analyzed according to clinical data and one-, two-, and five-year survival rates. hTERT expression in the cancerous tissue was significantly higher than in the lung parenchyma free from neoplasm infiltration (p<0.05). There was no significant association between hTERT expression in the tumor tissue and age, gender, grading or clinical stage. A significant difference in hTERT expression between two types of histopathological patterns (adenocarcinoma and squamous cell carcinoma) was detected (p=0.01). No association between hTERT expression in NSCLC specimens and survival rates was found. hTERT mRNA detection by QRT-PCR in tumor and corresponding cancer-free tissues can be used as a diagnostic marker in patients with NSCLC, but seems not to be a prognostic factor.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research