The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115 | Zendy

Andrzej Łazarenkow | Zendy; Marta Michalska | Zendy; Marek Mirowski | Zendy; Krzysztof Słomiak | Zendy; Jolanta NawrotModranka | Zendy

Open Access

The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115

Author(s) -

Andrzej Łazarenkow,

Marta Michalska,

Marek Mirowski,

Krzysztof Słomiak,

Jolanta NawrotModranka

Publication year - 2017

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2017_1565

Subject(s) - basic fibroblast growth factor , hydrazine (antidepressant) , fibroblast growth factor receptor 1 , cell culture , chemistry , fibroblast growth factor , melanoma , fibroblast , cell growth , cancer research , receptor , medicine , stereochemistry , endocrinology , pharmacology , biochemistry , growth factor , biology , genetics , in vitro

The hydrazine derivatives of benzopyrones remain an unexplored group of chemical compounds. This preliminary study investigates the influence of A-5, CH-3 and K-2 derivatives at concentrations of 1, 10, 100 nM and 1 μM on selected biochemical factors of a melanoma cell line WM-115, with regard to their potential angiogenic properties. The studied compounds were found to influence cell proliferation, as well as total protein, bFGF and FGFR1 concentration.

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