Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties. | Zendy

Grzegorz Framski | Zendy; Dariusz Wawrzyniak | Zendy; Zofia JahnzWechmann | Zendy; Agnieszka Szymańska-Michalak | Zendy; Adam Kraszewski | Zendy; Jan Barciszewski | Zendy; Jerzy Boryski | Zendy; Jacek Stawiński | Zendy

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Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties.

Author(s) -

Grzegorz Framski,

Dariusz Wawrzyniak,

Zofia JahnzWechmann,

Agnieszka Szymańska-Michalak,

Adam Kraszewski,

Jan Barciszewski,

Jerzy Boryski,

Jacek Stawiński

Publication year - 2016

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2016_1338

Subject(s) - ribonucleoside , nucleobase , guanine , hela , glioma , chemistry , cell culture , moiety , biochemistry , stereochemistry , cell , dna , cancer research , biology , rna , gene , nucleotide , genetics

Several ribonucleoside analogues with modifications in the nucleobase and sugar moiety have been screened for anti-glioma activity in the T98G glioma cell line using cervical (HeLa) cell line as reference human malignant cells, and lung fibroblast (MCR-5) cell line as non-cancerous reference cells. Among the investigated compounds, ribonucleosides containing 6-chloropurine (3), 7-guanine (5) and a pyrrolopyrimidine (18) as nucleobases, show promising anti-glioma activity with good selectivity indices, and can be considered as lead structures for further anti-cancer studies.

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