Ionizing radiation induces changes in profile of metabolites in serum of cancer patients | Zendy

Małgorzata Roś-Mazurczyk | Zendy; Anna Wojakowska | Zendy; Łukasz Marczak | Zendy; Krzysztof Polański | Zendy; Monika Pietrowska | Zendy; Karol Jelonek | Zendy; Iwona Domińczyk | Zendy; Agata Hajduk | Zendy; T. Rutkowski | Zendy; Krzysztof Składowski | Zendy; Piotr Widłak | Zendy

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Ionizing radiation induces changes in profile of metabolites in serum of cancer patients

Author(s) -

Małgorzata Roś-Mazurczyk,

Anna Wojakowska,

Łukasz Marczak,

Krzysztof Polański,

Monika Pietrowska,

Karol Jelonek,

Iwona Domińczyk,

Agata Hajduk,

T. Rutkowski,

Krzysztof Składowski,

Piotr Widłak

Publication year - 2016

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2016_1301

Subject(s) - amino acid , chemistry , ionizing radiation , radiation therapy , biosynthesis , metabolism , metabolomics , cancer , biomarker , biochemistry , metabolic pathway , irradiation , medicine , chromatography , enzyme , physics , nuclear physics

Radiotherapy causes molecular changes observed at the level of body fluids, which are potential biomarker candidates for assessment of radiation exposure. Here we analyzed radiotherapy-induced changes in a profile of small metabolites detected in sera of head and neck cancer patients using the gas chromatography coupled with mass spectrometry approach. There were about 20 compounds, including carboxylic acids, sugars, amines and amino acids, whose levels significantly differed between pre-treatment and post-treatment samples. Among metabolites upregulated by radiotherapy there was 3-hydroxybutyric acid, whose level increased about three times in post-treatment samples. Moreover, compounds affected by irradiation were associated with several metabolic pathways, including protein biosynthesis and amino acid metabolism.

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