Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review | Zendy

Jolanta Kiewisz | Zendy; Monika M. Kaczmarek | Zendy; Anna Pawłowska | Zendy; Zbigniew Kmieć | Zendy; Tomasz Stompór | Zendy

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Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review

Author(s) -

Jolanta Kiewisz,

Monika M. Kaczmarek,

Anna Pawłowska,

Zbigniew Kmieć,

Tomasz Stompór

Publication year - 2016

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2016_1284

Subject(s) - progenitor cell , progenitor , kidney , endothelial progenitor cell , medicine , intensive care medicine , biology , bioinformatics , stem cell , microbiology and biotechnology

Endothelial progenitor cells (EPCs) represent a small population of blood cells (5-40 cells/mm(3)), with an ability to differentiate into endothelial cells that form the lining of the blood vessels and contribute to postnatal angiogenesis. Abundant evidence shows that recruitment of EPCs from the bone marrow, the monocyte/macrophage lineage and the organs facilitate the endothelial regeneration and repair. Changes in the number of EPCs were observed in both, chronic kidney and cardiovascular diseases. Thus, these cells were tested for usage in diagnosis and therapy. In this paper, we review the current knowledge on the EPC biology and contribution of these cells to the kidney and cardiovascular diseases.

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