Virus-like particles as drug delivery vectors | Zendy

Michał Zdanowicz | Zendy; Jadwiga Chroboczek | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Virus-like particles as drug delivery vectors

Author(s) -

Michał Zdanowicz,

Jadwiga Chroboczek

Publication year - 2016

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2016_1275

Subject(s) - virus like particle , virus , heterologous , virology , computational biology , recombinant dna , gene delivery , biology , drug delivery , heterologous expression , microbiology and biotechnology , chemistry , gene , genetic enhancement , biochemistry , organic chemistry

Virus-like particles (VLPs) assemble spontaneously during the viral cycle or in heterologous systems during expression of viral structural protein. Depending on the complexity of the VLPs, they can be obtained by expression in prokaryotic or eukaryotic expression system from the suitable recombinant vectors, or formed in cell-free conditions. Moreover, they can be built from proteins of a single virus, or can present the proteins or peptides derived from a virus or cell on a platform derived from any other single virus, thus forming chimeric VLPs. VLPs are best known for their immunogenic properties, but the versatility of VLPs allows a wide variety of applications. They are lately in the centre of investigations in vaccinology, drug delivery and gene therapy. This review focuses on utilization of VLPs for drug delivery.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research