SOCS3 is epigenetically up-regulated in steroid resistant nephrotic children. | Zendy

Katarzyna Zaorska | Zendy; Piotr Zawierucha | Zendy; Danuta OstalskaNowicka | Zendy; Michał Nowicki | Zendy

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SOCS3 is epigenetically up-regulated in steroid resistant nephrotic children.

Author(s) -

Katarzyna Zaorska,

Piotr Zawierucha,

Danuta OstalskaNowicka,

Michał Nowicki

Publication year - 2016

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2015_1105

Subject(s) - nephrotic syndrome , steroid , biology , endocrinology , medicine , hormone

The mechanism of steroid resistance in children with the nephrotic syndrome is yet unknown. About 20% of patients demonstrate steroid unresponsiveness and progress to end stage renal disease. Aberrant SOCS3 and SOCS5 expression in steroid resistant and sensitive patients has previously been demonstrated. Here, we investigate genetic and epigenetic mechanisms of regulation of SOCS3 and SOCS5 transcription in nephrotic children.

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