The factor VIII protein and its function. | Zendy

Anna Mazurkiewicz-Pisarek | Zendy; Grażyna Płucienniczak | Zendy; Tomasz Ciach | Zendy; Andrzej Płucienniczak | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The factor VIII protein and its function.

Author(s) -

Anna Mazurkiewicz-Pisarek,

Grażyna Płucienniczak,

Tomasz Ciach,

Andrzej Płucienniczak

Publication year - 2016

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2015_1056

Subject(s) - factor ixa , coagulation , immunoglobulin light chain , chemistry , coagulation system , secretion , tissue factor , biochemistry , factor x , microbiology and biotechnology , medicine , immunology , biology , platelet , antibody , thrombin

Factor VIII (FVIII), an essential blood coagulation protein, is a key component of the fluid phase blood coagulation system. Human factor VIII is a single chain of about 300 kDa consisting of domains described as A1-A2-B-A3-C1-C2. The protein undergoes processing prior to secretion into blood resulting in a heavy chain of 200 kDa (A1-A2-B) and a light chain of 80 kDa (A3-C1-C2) linked by metal ions. The role of factor VIII is to increase the catalytic efficiency of factor IXa in the activation of factor X. Variants of these factors lead frequently also to severe bleeding disorders.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research