Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer | Zendy

Katarzyna Linkowska | Zendy; Arkadiusz Jawień | Zendy; Andrzej Marszałek | Zendy; Katarzyna Skonieczna | Zendy; Tomasz Grzybowski | Zendy

Open Access

Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer

Author(s) -

Katarzyna Linkowska,

Arkadiusz Jawień,

Andrzej Marszałek,

Katarzyna Skonieczna,

Tomasz Grzybowski

Publication year - 2015

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2014_935

Subject(s) - mitochondrial dna , biology , polymerase , gene , colorectal cancer , genetics , exon , microbiology and biotechnology , polymerase chain reaction , cancer , dna

Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome. Recent studies demonstrated an association of CAG repeat polymorphism in the second exon of POLG gene with the risk of cancer. We investigated the CAG repeat variability in the POLG gene in tumor and non-tumor tissues from colorectal cancer patients and in DNA samples isolated from blood obtained from age-matched healthy persons. Somatically occuring CAG-repeat alterations in cancer tissues have been observed in 10% of patients, but no association has been found between the CAG repeat variants in the POLG gene and colorectal cancer risk.

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