Skin metabolism established with the use of MetaSite for selected retinoids employed in topical and systemic treatment of various skin disorders and found in cosmeceuticals | Zendy

Karolina Słoczyńska | Zendy; Agnieszka GuniaKrzyżak | Zendy; Dorota Żelaszczyk | Zendy; Anna M. Waszkielewicz | Zendy; Henryk Marona | Zendy

Open Access

Skin metabolism established with the use of MetaSite for selected retinoids employed in topical and systemic treatment of various skin disorders and found in cosmeceuticals

Author(s) -

Karolina Słoczyńska,

Agnieszka GuniaKrzyżak,

Dorota Żelaszczyk,

Anna M. Waszkielewicz,

Henryk Marona

Publication year - 2015

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2014_891

Subject(s) - etretinate , chemistry , retinaldehyde , cytochrome p450 , acitretin , hydroxylation , metabolite , adapalene , biochemistry , stereochemistry , cyp1a2 , pharmacology , retinoic acid , metabolism , enzyme , psoriasis , dermatology , organic chemistry , medicine , benzoyl peroxide , polymerization , gene , polymer

Besides being widely used in cosmetics, retinoids are potent therapeutic agents used topically and systemically as anti-acne agents. The aim of this study was to predict with the use of MetaSite the skin metabolism of selected retinoids employed in treatment of skin disorders and found in cosmeceuticals. The following compounds were studied: retinol, retinaldehyde, retinoic acid, retinyl acetate, retinyl palmitate, acitretin, etretinate, adapalene and bexarotene.

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