A relationship between serological markers of chronic C. pneumoniae and CMV infection and hsp60 in patients with atherosclerotic carotid stenosis | Zendy

Maciej Rabczyński | Zendy; Żanna Fiodorenko-Dumas | Zendy; Krzysztof Mastej | Zendy; I. Dumas | Zendy; Rajmund Adamiec | Zendy; Małgorzata PaprockaBorowicz | Zendy

Open Access

A relationship between serological markers of chronic C. pneumoniae and CMV infection and hsp60 in patients with atherosclerotic carotid stenosis

Author(s) -

Maciej Rabczyński,

Żanna Fiodorenko-Dumas,

Krzysztof Mastej,

I. Dumas,

Rajmund Adamiec,

Małgorzata PaprockaBorowicz

Publication year - 2015

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2014_832

Subject(s) - hsp60 , serology , carotid endarterectomy , heat shock protein , antibody , immunology , medicine , immunohistochemistry , biology , stenosis , hsp70 , gene , biochemistry

A number of epidemiological studies conducted over the last decade indicate a relationship between specific pathogen infections and the development of atherosclerosis, although no pathogenetic pathways connecting these two have been determined. Recent reports support the role of heat shock proteins (HSPs) in atherogenesis. The HSPs are also believed to be a link between the infection and the development of atherosclerotic lesions. THE AIMS OF STUDY: Immunohistochemical evaluation of carotid artery segments to show the relationship between the presence of heat shock proteins and the serum levels of anti-hsp60 antibodies. An attempt to demonstrate a relationship between an expression of chronic C. pneumoniae and CMV antigens.

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