The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line. | Zendy

Andrzej Łazarenkow | Zendy; Marta Michalska | Zendy; Anna Gorąca | Zendy; Marek Mirowski | Zendy; Jolanta NawrotModranka | Zendy; Aleksandra Piechota-Polańczyk | Zendy

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The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line.

Author(s) -

Andrzej Łazarenkow,

Marta Michalska,

Anna Gorąca,

Marek Mirowski,

Jolanta NawrotModranka,

Aleksandra Piechota-Polańczyk

Publication year - 2013

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2013_1981

Subject(s) - chemistry , chromone , hydrazone , in vivo , lipid peroxidation , tbars , in vitro , flavones , biochemistry , antioxidant , stereochemistry , organic chemistry , chromatography , biology , microbiology and biotechnology

Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0%).

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