Cohesin Irr1/Scc3 is likely to influence transcription in Saccharomyces cerevisiae via interaction with Mediator complex. | Zendy

Agata Cena | Zendy; Marek Skoneczny | Zendy; Anna Chełstowska | Zendy; Piotr Kowalec | Zendy; Renata Natorff | Zendy; Anna Kurlandzka | Zendy

Open Access

Cohesin Irr1/Scc3 is likely to influence transcription in Saccharomyces cerevisiae via interaction with Mediator complex.

Author(s) -

Agata Cena,

Marek Skoneczny,

Anna Chełstowska,

Piotr Kowalec,

Renata Natorff,

Anna Kurlandzka

Publication year - 2013

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2013_1977

Subject(s) - saccharomyces cerevisiae , cohesin , coactivator , gene , transcription (linguistics) , biology , mediator , establishment of sister chromatid cohesion , genetics , transcription preinitiation complex , transcription factor , gene expression , microbiology and biotechnology , meiosis , promoter , linguistics , philosophy

The evolutionarily conserved proteins forming sister chromatid cohesion complex are also involved in the regulation of gene transcription. The participation of SA2p (mammalian ortholog of yeast Irr1p, associated with the core of the complex) in the regulation of transcription is already described. Here we analyzed microarray profiles of gene expression of a Saccharomyces cerevisiae irr1-1/IRR1 heterozygous diploid strain. We report that expression of 33 genes is affected by the presence of the mutated Irr1-1p and identify those genes. This supports the suggested role of Irr1p in the regulation of transcription. We also indicate that Irr1p may interact with elements of transcriptional coactivator Mediator.

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