Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer--the DNA microarray assay. | Zendy

Zoran Stojčev | Zendy; Tomasz Banasiewicz | Zendy; Michał Kaszuba | Zendy; Adam Sikorski | Zendy; Marek Szczepkowski | Zendy; Adam Bobkiewicz | Zendy; Jacek Paszkowski | Zendy; Łukasz Krokowicz | Zendy; Maciej Biczysko | Zendy; Jacek Szmeja | Zendy; Monika Jurkowska | Zendy; Przemysław Majewski | Zendy; Andrzej Maćkiewicz | Zendy; Katarzyna Lamperska | Zendy; Michał Drews | Zendy; Jacek Wojciechowicz | Zendy

Open Access

Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer--the DNA microarray assay.

Author(s) -

Zoran Stojčev,

Tomasz Banasiewicz,

Michał Kaszuba,

Adam Sikorski,

Marek Szczepkowski,

Adam Bobkiewicz,

Jacek Paszkowski,

Łukasz Krokowicz,

Maciej Biczysko,

Jacek Szmeja,

Monika Jurkowska,

Przemysław Majewski,

Andrzej Maćkiewicz,

Katarzyna Lamperska,

Michał Drews,

Jacek Wojciechowicz

Publication year - 2013

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2013_1971

Subject(s) - mlh1 , msh6 , colorectal cancer , microarray , dna microarray , msh2 , cancer , genetics , lynch syndrome , biology , gene , bioinformatics , medicine , dna mismatch repair , gene expression

Detection of mutations in families with a hereditary predisposition to colon cancer gives an opportunity to precisely define the high-risk group. 36 patients operated on for colon cancer, with familiar prevalence of this malignancy, were investigated using the DNA microarrays method with the potential detection of 170 mutations in MLH1, MSH2, MSH6, CHEK2, and NOD2 genes. In microarrays analysis of DNA in 9 patients (25% of the investigated group), 6 different mutations were found. The effectiveness of genetic screening using the microarray method is comparable to the effectiveness of other, much more expensive and time-consuming methods.

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