A focus on homocysteine in autism. | Zendy

Joanna KałużnaCzaplińska | Zendy; Ewa Żurawicz | Zendy; Monika Michalska | Zendy; Jacek Rynkowski | Zendy

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A focus on homocysteine in autism.

Author(s) -

Joanna KałużnaCzaplińska,

Ewa Żurawicz,

Monika Michalska,

Jacek Rynkowski

Publication year - 2013

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2013_1963

Subject(s) - homocysteine , cobalamin , autism , pyridoxine , hyperhomocysteinemia , vitamin b12 , biochemistry , medicine , biology , psychiatry

Homocysteine is an amino acid, which plays several important roles in human physiology. A wide range of disorders, including neuropsychiatric disorders and autism, are associated with increased homocysteine levels in biological fluids. Various B vitamins: B6 (pyridoxine), B12 (cobalamin), and B9 (folic acid) are required as co-factors by the enzymes involved in homocysteine metabolism. Therefore, monitoring of homocysteine levels in body fluids of autistic children can provide information on genetic and physiological diseases, improper lifestyle (including dietary habits), as well as a variety of pathological conditions. This review presents information on homocysteine metabolism, determination of homocysteine in biological fluids, and shows abnormalities in the levels of homocysteine in the body fluids of autistic children.

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