Denaturation and aggregation of lysozyme in water-ethanol solution. | Zendy

Agnieszka Szymańska | Zendy; T. Hornowski | Zendy; Genowefa Ślósarek | Zendy

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Denaturation and aggregation of lysozyme in water-ethanol solution.

Author(s) -

Agnieszka Szymańska,

T. Hornowski,

Genowefa Ślósarek

Publication year - 2012

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2012_2158

Subject(s) - lysozyme , chemistry , rheology , ethanol , denaturation (fissile materials) , shear thinning , chemical engineering , chromatography , protein aggregation , biochemistry , materials science , nuclear chemistry , engineering , composite material

We have applied rheological methods for the analysis of ethanol-lysozyme interaction during the process of denaturation and aggregation of the protein. At low concentration of ethanol a destruction of the hydration shell of lysozyme is observed. With the increase in the ethanol concentration a structural transformation takes place. It leads to the formation of a protein aggregate with an elongated structure. The rheological characteristics of lysozyme-water-ethanol solution changes from Newtonian to pseudoplastic.

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