Effect of substrate stiffness on differentiation of umbilical cord stem cells. | Zendy

Małgorzata Witkowska-Zimny | Zendy; Katarzyna Walenko | Zendy; Anna Ewa Wałkiewicz | Zendy; Zygmunt Pojda | Zendy; Jacek Przybylski | Zendy; M. LewandowskaSzumieł | Zendy

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Effect of substrate stiffness on differentiation of umbilical cord stem cells.

Author(s) -

Małgorzata Witkowska-Zimny,

Katarzyna Walenko,

Anna Ewa Wałkiewicz,

Zygmunt Pojda,

Jacek Przybylski,

M. LewandowskaSzumieł

Publication year - 2012

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2012_2148

Subject(s) - mesenchymal stem cell , regenerative medicine , umbilical cord , microbiology and biotechnology , wharton's jelly , stem cell , chemistry , cellular differentiation , cord lining , stromal cell , substrate (aquarium) , biophysics , cell , biomedical engineering , materials science , anatomy , biology , biochemistry , adult stem cell , medicine , cancer research , ecology , gene

Tissue formation and maintenance is regulated by various factors, including biological, physiological and physical signals transmitted between cells as well as originating from cell-substrate interactions. In our study, the osteogenic potential of mesenchymal stromal/stem cells isolated from umbilical cord Wharton's jelly (UC-MSCs) was investigated in relation to the substrate rigidity on polyacrylamide hydrogel (PAAM). Osteogenic differentiation of UC-MSCs was enhanced on stiff substrate compared to soft substrates, illustrating that the mechanical environment can play a role in differentiation of this type of cells. These results show that substrate stiffness can regulate UC-MSCs differentiation, and hence may have significant implications for design of biomaterials with appropriate mechanical properties for regenerative medicine.

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