Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage. | Zendy

Edyta Biskup | Zendy; Marek Gołębiowski | Zendy; Robert Gniadecki | Zendy; Piotr Stepnowski | Zendy; Ewa Łojkowska | Zendy

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Triterpenoid α-amyrin stimulates proliferation of human keratinocytes but does not protect them against UVB damage.

Author(s) -

Edyta Biskup,

Marek Gołębiowski,

Robert Gniadecki,

Piotr Stepnowski,

Ewa Łojkowska

Publication year - 2012

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2012_2147

Subject(s) - hacat , terpenoid , chemistry , traditional medicine , cell growth , keratinocyte , pharmacology , biochemistry , biology , in vitro , medicine

Rhaponticum carthamoides plants ("maral root") are widely used in Siberian folk medicine. The present study reports for the first time the presence of pentacyclic terpenoid, α-amyrin, in methanol extract from leaves of this plant. α-Amyrin induced proliferation of human keratinocytes (HaCaT) by about 18% while other extract components were ineffective. A panel of biochemical and cell-based assays testing the antioxidative and cytoprotective activites of α-amyrin indicated no antioxidative activity of this compound. α-Amyrin did not protect HaCaT cells against the damage caused by UVB radiation.

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