Open AccessIndirect inactivation of tyrosinase in its action on tyrosine.
Author(s) -
José Muñoz-Muñoz,
Francisco Garcı́a-Molina,
José Ramón AcostaMotos,
Enrique Arribas Garde,
Pedro Antonio Garcı́a-Ruiz,
José Tudela,
Francisco Garcı́a-Cánovas,
José Neptuno RodríguezLópez
Publication year - 2011
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.2011_2214
Subject(s) - tyrosinase , tyrosine , chemistry , enzyme , anaerobic exercise , biochemistry , biology , physiology
Under aerobic conditions, tyrosinase is inactivated by dopa as a result of suicide inactivation, and, under anaerobic conditions, as a result of irreversible inactivation. However, tyrosine protects the enzyme from being inactivated by dopa under anaerobic conditions. This paper describes how under aerobic conditions the enzyme acting on tyrosine is not directly inactivated but undergoes a process of indirect suicide inactivation provoked by reaction with the o-diphenol originated from the evolution of o-dopaquinone and accumulated in the reaction medium.
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