In vitro effects of compounds isolated from Sideritis brevibracteata on bovine kidney cortex glutathione reductase. | Zendy

Berivan Tandoğan | Zendy; Ayşegül Güvenç | Zendy; İhsan Çalış | Zendy; Nuriye Nuray Ulusu | Zendy

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In vitro effects of compounds isolated from Sideritis brevibracteata on bovine kidney cortex glutathione reductase.

Author(s) -

Berivan Tandoğan,

Ayşegül Güvenç,

İhsan Çalış,

Nuriye Nuray Ulusu

Publication year - 2011

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2011_2213

Subject(s) - glutathione , chemistry , glutathione reductase , in vitro , flavones , biochemistry , antioxidant , glycoside , enzyme , stereochemistry , chromatography , glutathione peroxidase

Glutathione reductase (GR, E.C 1.6.4.2) is a flavoprotein that catalyzes NADPH-dependent reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH). The aim of this study was to investigate in vitro effects of phenolic compounds isolated from Sideritis brevibracteata on bovine kidney GR. The Sideritis species are widely found in nature and commonly used as medicinal plants. 7-O-glycosides of 8-OH-flavones (hypolaetin, isoscutellarein and 3'-hydroxy-4'-O-methylisoscutellarein) were isolated from aerial parts of Sideritis brevibracteata. These compounds inhibited bovine kidney cortex GR in a concentration-dependent manner. Kinetic characterization of the inhibition was also performed.

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