Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity. | Zendy

Konrad Plata | Zendy; Adriana E. Rosato | Zendy; Grzegorz Węgrzyn | Zendy

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Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity.

Author(s) -

Konrad Plata,

Adriana E. Rosato,

Grzegorz Węgrzyn

Publication year - 2009

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2009_2491

Subject(s) - staphylococcus aureus , virulence , pathogenicity , biology , microbiology and biotechnology , pathogenicity island , pathogen , human pathogen , genome , gene , population , genetics , bacteria , medicine , environmental health

Although it is estimated that 20-30% of the general human population are carriers of Staphylococcus aureus, this bacterium is one of the most important etiological agents responsible for healthcare-associated infections. The appearance of methicillin resistant S. aureus (MRSA) strains has created serious therapeutical problems. Detailed understanding of the mechanisms of S. aureus infections seems necessary to develop new effective therapies against this pathogen. In this article, we present an overview of the biochemical and genetic mechanisms of pathogenicity of S. aureus strains. Virulence factors, organization of the genome and regulation of expression of genes involved in virulence, and mechanisms leading to methicilin resistance are presented and briefly discussed.

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