Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements. | Zendy

Joanna Szczepanowska | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements.

Author(s) -

Joanna Szczepanowska

Publication year - 2009

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2009_2453

Subject(s) - cdc42 , pak1 , microbiology and biotechnology , cytoskeleton , gtpase , kinase , serine , biology , threonine , rac1 , phosphorylation , carcinogenesis , signal transduction , genetics , cell , gene

The p21-activated kinases (PAKs) are serine/threonine protein kinases interacting with small GTPases - Rac and Cdc42. PAKs are found in most eukaryotes and play an evolutionarily conserved role in many cellular processes. Six human PAKs have been identified, and based on homology, they can be classified into two groups. This review focuses specifically on the role of Rac/Cdc42 regulated PAKs in maintaining and remodeling cytoskeletal structure in various organisms. A list of PAKs substrates and binding partners implicated directly and indirectly in cytoskeletal reorganization is presented. Also perturbations of the Rac/Cdc42/PAK pathway leading to tumorigenesis and neurodegenerative diseases are reviewed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research