Overexpression of human CUTA isoform2 enhances the cytotoxicity of copper to HeLa cells. | Zendy

Jingchun Yang | Zendy; Qiang Li | Zendy; Huirong Yang | Zendy; Lichong Yan | Zendy; Yang Liu | Zendy; Long Yu | Zendy

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Overexpression of human CUTA isoform2 enhances the cytotoxicity of copper to HeLa cells.

Author(s) -

Jingchun Yang,

Qiang Li,

Huirong Yang,

Lichong Yan,

Yang Liu,

Long Yu

Publication year - 2008

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2008_3089

Subject(s) - hela , copper , cytotoxicity , copper toxicity , apoptosis , microbiology and biotechnology , chemistry , toxicity , homeostasis , cell , in vitro , biochemistry , biology , organic chemistry

Copper, an essential transient element, can be toxic to cells when present in excess. Altered copper homeostasis is involved in pathological events of many diseases. Human CUTA isoform2 is a member of cation tolerance protein (CutA1) family. In this study, we examined the effect of CUTA isoform2 overexpression on copper toxicity. It was shown that overexpressed CUTA isoform2 sensitized HeLa cells to copper toxicity by promoting copper-induced apoptosis. The inhibition effect of excessive copper on cell proliferation was also enhanced by overexpressed CUTA isoform2. So CUTA isoform2 was implicated to be involved in the cytotoxicity of copper.

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