Photodynamic effect of lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus. | Zendy

Agata Jurczak-Kurek | Zendy; Bozena Szramka | Zendy; Mariusz Grinholc | Zendy; J. Legendziewicz | Zendy; Krzysztof Piotr Bielawski | Zendy

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Photodynamic effect of lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus.

Author(s) -

Agata Jurczak-Kurek,

Bozena Szramka,

Mariusz Grinholc,

J. Legendziewicz,

Krzysztof Piotr Bielawski

Publication year - 2008

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2008_3064

Subject(s) - porphyrin , photosensitizer , photodynamic therapy , lanthanide , staphylococcus aureus , chemistry , tetra , bacteria , photochemistry , reactive oxygen species , combinatorial chemistry , microbiology and biotechnology , ion , medicinal chemistry , biochemistry , organic chemistry , biology , genetics

Photodynamic therapy (PDT), used for cancer treatment, is also an alternative method for eradication of drug-resistant bacteria. This method utilizes a nontoxic light-activated dye, called a photosensitizer, and visible light to produce reactive oxygen species that lead to bacterial cell death. The purpose of this study was to investigate the bactericidal effect of PDT using lanthanide derivatives of meso-tetra(N-methyl-4-pyridyl)porphine against Staphylococcus aureus strains. The new photosensitizers appeared to be photodynamically ineffective. No enhancement of antistaphylococcal activity of TMPyP was observed after the conjugation of the porphyrin with lanthanide ions. Additionally, a significant difference in the susceptibility of two bacterial strains to unmodified TMPyP was observed.

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