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Photodynamic therapy (PDT) is based on photosensitizers activated by light of appropriate wave - length. Their activation leads to generation of singlet oxygen and free radicals responsible for the cytotoxic effect. The aim of this project was to compare the bactericidal effect of PDT using different porphyrin photosensitizers against a methicillin-resistant Staphylococcus aureus strain. Exogenous sensitizers (protoporphyrin IX and newly synthesized derivative, protoporphyrin di - arginate) induced a 3 log 10-unit reduction in bacterial viable counts. With the use of endogenous, ALA-induced porphyrins, a 1.6 log 10-unit reduction was obtained. The sensitizers tested execut - ed their antibacterial activity with no essential change in the antibiotic resistance pattern of the studied strain.

acta biochimica polonica

Bactericidal effect of photodynamic therapy against methicillin-resistant Staphylococcus aureus strain with the use of various porphyrin photosensitizers.