Bactericidal effect of photodynamic therapy against methicillin-resistant Staphylococcus aureus strain with the use of various porphyrin photosensitizers. | Zendy

Mariusz Grinholc | Zendy; Bozena Szramka | Zendy; Katarzyna Olender | Zendy; Alfreda Graczyk | Zendy

Open Access

Bactericidal effect of photodynamic therapy against methicillin-resistant Staphylococcus aureus strain with the use of various porphyrin photosensitizers.

Author(s) -

Mariusz Grinholc,

Bozena Szramka,

Katarzyna Olender,

Alfreda Graczyk

Publication year - 2007

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2007_3240

Subject(s) - photodynamic therapy , protoporphyrin ix , porphyrin , singlet oxygen , staphylococcus aureus , chemistry , photosensitizer , protoporphyrin , strain (injury) , microbiology and biotechnology , photochemistry , oxygen , bacteria , medicine , biology , organic chemistry , genetics

Photodynamic therapy (PDT) is based on photosensitizers activated by light of appropriate wave - length. Their activation leads to generation of singlet oxygen and free radicals responsible for the cytotoxic effect. The aim of this project was to compare the bactericidal effect of PDT using different porphyrin photosensitizers against a methicillin-resistant Staphylococcus aureus strain. Exogenous sensitizers (protoporphyrin IX and newly synthesized derivative, protoporphyrin di - arginate) induced a 3 log 10-unit reduction in bacterial viable counts. With the use of endogenous, ALA-induced porphyrins, a 1.6 log 10-unit reduction was obtained. The sensitizers tested execut - ed their antibacterial activity with no essential change in the antibiotic resistance pattern of the studied strain.

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