Synthesis, antimicrobial activity and structural studies of low molecular mass lysine dendrimers. | Zendy

Jolanta Janiszewska | Zendy; Z. Urbańczyk-Lipkowska | Zendy

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Synthesis, antimicrobial activity and structural studies of low molecular mass lysine dendrimers.

Author(s) -

Jolanta Janiszewska,

Z. Urbańczyk-Lipkowska

Publication year - 2006

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2006_3364

Subject(s) - dendrimer , lysine , chemistry , antimicrobial , solid phase synthesis , candida albicans , molecule , combinatorial chemistry , molecular mass , escherichia coli , mass spectrometry , staphylococcus aureus , fragmentation (computing) , biochemistry , stereochemistry , organic chemistry , bacteria , amino acid , peptide , microbiology and biotechnology , chromatography , biology , enzyme , ecology , gene , genetics

Four low molecular mass lysine dendrimers were synthesized by Boc chemistry in solution (155 and 169) and Fmoc chemistry on solid support (P2 and P13). The structure and fragmentation mode of the above dendrimers was investigated in gas phase by the LSI-MS and ESI-MS techniques. (1)H and (13)C NMR analysis in solution (d(6)-DMSO) allowed to confirm the correct structure. Antimicrobial activities of the dendrimers against Staphylococcus aureus, Escherichia coli and Candida albicans confirmed our hypothesis that the dendrimer structure can be used for construction of molecules interacting with biological membranes.

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