Genetic models to study adult neurogenesis. | Zendy

Robert K. Filipkowski | Zendy; Anna Kiryk | Zendy; Anna Kowalczyk | Zendy; Leszek Kaczmarek | Zendy

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Genetic models to study adult neurogenesis.

Author(s) -

Robert K. Filipkowski,

Anna Kiryk,

Anna Kowalczyk,

Leszek Kaczmarek

Publication year - 2005

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2005_3449

Subject(s) - neurogenesis , olfactory bulb , neuroscience , biology , hippocampus , transcription factor , cyclin , central nervous system , microbiology and biotechnology , genetics , cell cycle , cell , gene

In the central nervous system (CNS) generation of new neurons continues throughout adulthood, when it is limited to the olfactory bulb and hippocampus. The knowledge regarding the function of newly-generated neurons remains limited and is vigorously investigated using diverse approaches. Among these are genetically modified mice, most of them of knock-out type (KO). Results from 23 diverse KO mouse models demonstrate the importance of particular proteins (growth factors, nitric oxide synthases, receptors, cyclins/cyclin-associated proteins, transcription factors, etc.) in adult neurogenesis (ANGE) as well as separate it from developmental neurogenesis. These results bring us closer to revealing the function of newly generated neurons in adult brains.

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