The chaperone-usher pathway of bacterial adhesin biogenesis -- from molecular mechanism to strategies of anti-bacterial prevention and modern vaccine design. | Zendy

Rafał Piątek | Zendy; Beata Zalewska-Piątek | Zendy; Katarzyna Bury | Zendy; Józef Kur | Zendy

Open Access

The chaperone-usher pathway of bacterial adhesin biogenesis -- from molecular mechanism to strategies of anti-bacterial prevention and modern vaccine design.

Author(s) -

Rafał Piątek,

Beata Zalewska-Piątek,

Katarzyna Bury,

Józef Kur

Publication year - 2005

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2005_3424

Subject(s) - chaperone (clinical) , biogenesis , pilus , bacterial adhesin , fimbria , bacteria , microbiology and biotechnology , virulence , biofilm , biology , bacterial cell structure , bacterial outer membrane , chemistry , escherichia coli , genetics , gene , medicine , pathology

The chaperone-usher system determines the biogenesis of surface-exposed adhesive structures responsible for virulence of many Gram-negative bacteria. Investigations of the last 20 years have resolved the mechanism of this pathway on a structural level for different species of pathogenic bacteria. The purpose of this review is to present the molecular mechanisms of the biogenesis of adhesive structures assembled via the chaperone-usher pathway. The obtained mechanistic data allow one to propose potential strategies of anti-bacterial action. Additionally, the specific properties of the polymeric adhesive structures (pili and fimbriae) of the chaperone-usher system allow their use as effective and safe recombinant vaccines carrying foreign epitopes in thousands of copies on bacterial cell surface.

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