Interaction of class A G protein-coupled receptors with G proteins. | Zendy

Rafał Ślusarz | Zendy; Jerzy Ciarkowski | Zendy

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Interaction of class A G protein-coupled receptors with G proteins.

Author(s) -

Rafał Ślusarz,

Jerzy Ciarkowski

Publication year - 2004

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2004_3604

Subject(s) - transducin , rhodopsin , g protein , g protein coupled receptor , protein subunit , peptide , helix (gastropod) , alpha helix , receptor , chemistry , dimer , g alpha subunit , protein structure , protein–protein interaction , gtp binding protein regulators , stereochemistry , biology , biochemistry , gene , retinal , ecology , snail , organic chemistry

A model for interaction of class A G protein-coupled receptor with the G protein G(alpha) subunit is proposed using the rhodopsin-transducin (RD/Gt) prototype. The model combines the resolved interactions/distances, essential in the active RD*/Gt system, with the structure of Gt(alpha) C-terminal peptide bound to RD* while stabilizing it. Assuming the interactions involve conserved parts of the partners, the model specifies the conserved Helix 2 non-polar X- - -X, Helix 3 DRY and Helix 7/8 NP- -Y- - F RD* motifs interacting with the Gt(alpha) C-terminal peptide, in compliance with the structure of the latter. A concomitant role of Gt(alpha) and Gt(gamma) C-termini in stabilizing RD* could possibly be resolved assuming a receptor dimer as requisite for G protein activation.

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