Biological evaluation of analogues of an insect neuropeptide proctolin. | Zendy

Iwona Woźnica | Zendy; Wioletta Szeszel-Fedorowicz | Zendy; Grzegorz Rosińskiand | Zendy; Danuta Konopińska | Zendy

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Biological evaluation of analogues of an insect neuropeptide proctolin.

Author(s) -

Iwona Woźnica,

Wioletta Szeszel-Fedorowicz,

Grzegorz Rosińskiand,

Danuta Konopińska

Publication year - 2004

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2004_3602

Subject(s) - proctolin , schistocerca , foregut , neuropeptide , insect , peptide , biological activity , in vitro , chemistry , biochemistry , fmrfamide , biology , anatomy , botany , locust , receptor

Continuing our studies on proctolin (Arg-Tyr-Leu-Pro-Thr) we performed the synthesis and biological evaluation of 52 analogues substituted in position 2, 3, 4, and 5 of the peptide chain. The peptides were bioassayed for cardiotropic activity in vitro on Tenebrio molitor and myotropic activity on foregut of Schistocerca gregaria. Twenty analogues retained 20-80% of proctolin activity.

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