New analogue of cyclolinopeptide B modified by amphiphilic residue of alpha-hydroxymethylmethionine. | Zendy

R Witkowska | Zendy; Anna Donigiewicz | Zendy; Michał Zimecki | Zendy; Janusz Zabrocki | Zendy

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New analogue of cyclolinopeptide B modified by amphiphilic residue of alpha-hydroxymethylmethionine.

Author(s) -

R Witkowska,

Anna Donigiewicz,

Michał Zimecki,

Janusz Zabrocki

Publication year - 2004

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2004_3597

Subject(s) - residue (chemistry) , methionine , peptide , amphiphile , chemistry , biological activity , stereochemistry , immune system , biochemistry , in vitro , amino acid , biology , organic chemistry , immunology , copolymer , polymer

In order to evaluate the role and influence of the methionine residue on the biological activity of cyclolinopeptide B, an analogue with methionine residue in position 7 replaced by the amphiphilic (S)-alpha-hydroxymethylmethionine residue was synthesized. This peptide exhibits high immunosuppressive activity in the cellular, and to a lesser degree in the humoral immune response, comparable to that of CsA. In addition, the peptide was devoid of toxicity, even at high doses.

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