Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures. | Zendy

Anna Zalewska | Zendy; Małgorzata M. Brzóska | Zendy; Justyna Marciniak | Zendy; Katarzyna Karaszewska | Zendy; Krzysztof Zwierz | Zendy; J Moniuszko-Jakoniuk | Zendy

Open Access

Activity of lysosomal exoglycosidases in submandibular glands of rats intoxicated by cadmium at doses related to human chronic environmental and occupational exposures.

Author(s) -

Anna Zalewska,

Małgorzata M. Brzóska,

Justyna Marciniak,

Katarzyna Karaszewska,

Krzysztof Zwierz,

J Moniuszko-Jakoniuk

Publication year - 2004

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2004_3566

Subject(s) - cadmium , glycoconjugate , chemistry , endocrinology , medicine , biochemistry , biology , organic chemistry

Work in cadmium (Cd) smelter and smoking cigarettes damages teeth and oral mucosa which are protected by tissue and salivary glycoconjugates: glycoproteins, glycolipids, and proteoglycans. We worked out a rat model imitating human "environmental" and "occupational" exposure to cadmium using 5 mg Cd and 50 mg Cd/l in drinking water, respectively. In submandibulary glands of exposed to Cd rats, we found the time and dose dependent accumulation of Cd and simultanous decrease in activity of beta-N-acetylhexosaminidase (HEX). In homogenates of submandibulary glands of control rats, beta-N-acetylhexosaminidase showed the highest activity. The activities of alpha-mannosidase and beta-galactosidase were very low. None of these exoglycosidases were inhibited by Cd even at 44 mM concentration.

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