Preliminary studies of phthalocyanine sensitizers incorporated into human leukemia cells from two cell-lines. | Zendy

Krzysztof Wiktorowicz | Zendy; Justyna Cofta | Zendy; Alina Dudkowiak | Zendy; Aneta Waszkowiak | Zendy; D. Frąckowiak | Zendy

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Preliminary studies of phthalocyanine sensitizers incorporated into human leukemia cells from two cell-lines.

Author(s) -

Krzysztof Wiktorowicz,

Justyna Cofta,

Alina Dudkowiak,

Aneta Waszkowiak,

D. Frąckowiak

Publication year - 2004

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2004_3555

Subject(s) - phthalocyanine , photodynamic therapy , chemistry , leukemia , fluorescence , cell culture , photochemistry , cell , organic dye , membrane , biophysics , biochemistry , organic chemistry , biology , immunology , chemical engineering , physics , genetics , engineering , quantum mechanics

Three phthalocyanine dyes-sensitizers were incorporated into two types of human T leukemia cells from two cell-lines: CCRF and MOLT 4. The efficiency of the dye incorporation into cells and photochemical properties of stained cells were investigated using fluorescence spectroscopy. The dyes exhibited different properties in each of the two cell-lines. Small differences in cell membrane properties have a strong influence on the efficiency of dye incorporation and on the course of photodynamic reaction. It is suggested that, for a given patient, an optimal dye-sensitizer should be established before photodynamic treatment.

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