High levels of bulky DNA adducts in human sperm correlate with impaired fertility. | Zendy

Stanisław Horák | Zendy; Joanna Polańska | Zendy; Piotr Widłak | Zendy

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High levels of bulky DNA adducts in human sperm correlate with impaired fertility.

Author(s) -

Stanisław Horák,

Joanna Polańska,

Piotr Widłak

Publication year - 2003

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2003_3727

Subject(s) - sperm , fertility , adduct , dna , andrology , dna damage , chemistry , dna adduct , genetics , biology , medicine , biochemistry , organic chemistry , population , environmental health

Progressive decline in fertility and sperm quality has been reported over the last few decades, especially in industrialized nations. It has been proposed that exposure to factors that induce damage in DNA of spermatogenic cells may significantly contribute to impaired fertility. Here, the (32)P-postlabelling method was used to analyze the levels of bulky DNA adducts in sperm cells in a group of 179 volunteers, either healthy subjects or patients with an impaired fertility. The levels of DNA adducts were 1.35-fold higher in the infertile group as compared to healthy individuals (P = 0.012). Similarly, a significant negative correlation between the levels of DNA adducts and measures of semen quality (sperm concentration and motility) has been observed (P

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