Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell. | Zendy

Anna-Maria Ochocka | Zendy; Tadeusz Pawełczyk | Zendy

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Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell.

Author(s) -

Anna-Maria Ochocka,

Tadeusz Pawełczyk

Publication year - 2003

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2003_3634

Subject(s) - isozyme , phosphoinositide phospholipase c , diacylglycerol kinase , phospholipase c , second messenger system , signal transduction , gq alpha subunit , inositol , phospholipase , biology , protein kinase c , enzyme , biochemistry , inositol trisphosphate , microbiology and biotechnology , chemistry , g protein , receptor

Phospholipase C (PLC, EC 3.1.4.11) is an enzyme crucial for the phosphoinositol pathway and whose activity is involved in eukaryotic signal transduction as it generates two second messengers: diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). There are four major types of phospholipase C named: beta, gamma, delta and the recently discovered epsilon, but this review will focus only on the recent advances for the delta isozymes of PLC. So far, four delta isozymes (named delta1-4) have been discovered and examined. They differ with regard to cellular distribution, activities, biochemical features and involvement in human ailments.

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