Selectivity of oxidative stress targeting in estrogen-induced experimental nephrocarcinogenesis. | Zendy

Jarek Kobiela | Zendy; J Krajewski | Zendy; Beata Kalińska-Błach | Zendy; Tomasz Stefaniak | Zendy

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Selectivity of oxidative stress targeting in estrogen-induced experimental nephrocarcinogenesis.

Author(s) -

Jarek Kobiela,

J Krajewski,

Beata Kalińska-Błach,

Tomasz Stefaniak

Publication year - 2002

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2002_3820

Subject(s) - oxidative stress , endoplasmic reticulum , estrogen , subcellular localization , chemistry , oxidative phosphorylation , unfolded protein response , hamster , microbiology and biotechnology , biochemistry , endocrinology , medicine , biology , cytoplasm

Specificity of targeting of the oxidative stress towards lipid and protein fractions in a model of estrogen-induced Syrian hamster nephrocarcinogenesis was evaluated. The amount of proteins modified by oxidative stress was significantly elevated as early as one month after the initial implantation of estradiol to the experimental versus the control group, while the stress did not affect lipids. Subcellular localization of the oxidative stress target was determined by the analysis of protein oxidation in subcellular fractions of kidney cells. The endoplasmic reticulum membranes were the fraction most affected by the oxidative stress.

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