Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells. | Zendy

L.M. Nosach | Zendy; Nataliya Dyachenko | Zendy; V. L. Zhovnovataya | Zendy; Miron O. Lozinskiy | Zendy; V. Lozitsky | Zendy

Open Access

Inhibition of proteolytic processing of adenoviral proteins by epsilon-aminocaproic acid and ambenum in adenovirus-infected cells.

Author(s) -

L.M. Nosach,

Nataliya Dyachenko,

V. L. Zhovnovataya,

Miron O. Lozinskiy,

V. Lozitsky

Publication year - 2002

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2002_3760

Subject(s) - aminocaproic acid , proteolytic enzymes , chemistry , endogeny , proteolysis , adenovirus infection , microbiology and biotechnology , biochemistry , biology , virology , enzyme , virus

Maturation of adenovirus particles is markedly affected by proteolytic processing. The possibility for blocking the conversion of precursor structural core protein (preVII) into mature structure protein VII by officinal drugs epsilon-aminocaproic acid and ambenum has been demonstrated in Hep-2 cells infected with adenovirus. Proteolytic processing may be regarded as one of the targets for inhibiting adenovirus reproduction.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research