Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells. | Zendy

Rafał Czajkowski | Zendy; Jolanta Barańska | Zendy

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Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells.

Author(s) -

Rafał Czajkowski,

Jolanta Barańska

Publication year - 2002

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2002_3747

Subject(s) - p2y receptor , adenylyl cyclase , phospholipase c , nucleotide , receptor , signal transduction , phosphoinositide phospholipase c , inositol , extracellular , microbiology and biotechnology , purinergic receptor , p2 receptor , enzyme , biochemistry , phospholipase , adenylate kinase , adenosine , biology , chemistry , gene

In this review we summarize the present status of our knowledge on the enzymes involved in the extracellular metabolism of nucleotides and the receptors involved in nucleotide signalling. We focus on the mechanism of the ATP and ADP signalling pathways in glioma C6, representative of the type of nonexcitable cells. In these cells, ATP acts on the P2Y(2) receptor coupled to phospholipase C, whereas ADP on two distinct P2Y receptors: P2Y(1) and P2Y(12). The former is linked to phospholipase C and the latter is negatively coupled to adenylyl cyclase. The possible cross-talk between the ATP-, ADP- and adenosine-induced pathways, leading to simultaneous regulation of inositol 1,4,5-trisphosphate and cAMP mediated signalling, is discussed.

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