Actin in human colon adenocarcinoma cells with different metastatic potential. | Zendy

Dorota Nowak | Zendy; Agnieszka Krawczenko | Zendy; Danuta Duś | Zendy; Maria Malicka-Błaszkiewicz | Zendy

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Actin in human colon adenocarcinoma cells with different metastatic potential.

Author(s) -

Dorota Nowak,

Agnieszka Krawczenko,

Danuta Duś,

Maria Malicka-Błaszkiewicz

Publication year - 2002

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2002_3742

Subject(s) - actin , adenocarcinoma , cytosol , polymerization , chemistry , cell culture , colon adenocarcinoma , cell , cancer research , microbiology and biotechnology , biology , biochemistry , cancer , genetics , enzyme , organic chemistry , polymer

Four human colon adenocarcinoma cell line variants with different metastatic potential were used to examine whether a correlation exists between actin level, state of actin polymerization and invasiveness of tumour cells. Monomeric (G), total (T) and filamentous (F) actin were determined in the cytosolic fraction of these cells. A statistically significant decrease in G actin level and increase in the state of actin polymerization (measured by F:G actin ratio) were found in the cytosol of three cell variants with higher metastatic potential and invasiveness (EB3, 3LNLN, 5W) compared with the parental cell line (LS180). Our experimental data lead to the conclusion that there is a correlation between the metastatic capacity of human colon adenocarcinoma cells and the state of actin polymerization.

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