Directionality of kinesin motors. | Zendy

Andrzej A. Kasprzak | Zendy; Łukasz Hajdo | Zendy

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Directionality of kinesin motors.

Author(s) -

Andrzej A. Kasprzak,

Łukasz Hajdo

Publication year - 2002

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2002_3741

Subject(s) - kinesin , microtubule , directionality , molecular motor , motor protein , atp hydrolysis , movement (music) , chemistry , biophysics , microbiology and biotechnology , biology , physics , biochemistry , genetics , atpase , enzyme , acoustics

Kinesins are molecular motors that transport various cargoes along microtubule tracks using energy derived from ATP hydrolysis. Although the motor domains of kinesins are structurally similar, the family contains members that move on microtubules in opposite directions. Recent biochemical and biophysical studies of several kinesins make it possible to identify structural elements responsible for the different directionality, suggesting that reversal of the motor movement can be achieved through small, local changes in the protein structure.

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