Therapeutical effect of modified adamantane copolymer compounds: study of molecular mechanisms. | Zendy

С. Л. Рыбалко | Zendy; Н. Н. Нестерова | Zendy; S. T. Diadiun | Zendy; G Danylenko | Zendy; V P Danylenko | Zendy; S. V. Guzhova | Zendy; Yu. N. Maksimov | Zendy; V. G. Arkadiev | Zendy; N. V. Ivans'ka | Zendy; O Maksymenok | Zendy; N Vrnycianu | Zendy; E Zhtrebtsova | Zendy; T Grygoreva | Zendy

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Therapeutical effect of modified adamantane copolymer compounds: study of molecular mechanisms.

Author(s) -

С. Л. Рыбалко,

Н. Н. Нестерова,

S. T. Diadiun,

G Danylenko,

V P Danylenko,

S. V. Guzhova,

Yu. N. Maksimov,

V. G. Arkadiev,

N. V. Ivans'ka,

O Maksymenok,

N Vrnycianu,

E Zhtrebtsova,

T Grygoreva

Publication year - 2001

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2001_5132

Subject(s) - adamantane , virus , in ovo , virology , in vitro , biology , titer , dna , chemistry , microbiology and biotechnology , embryo , biochemistry , organic chemistry

Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible permissive cell cultures and chicken embryos. In AB-4 treated cells and allantoic sacs, virus titers (influenza virus, herpes virus, and HIV) and virus antigen concentration were decreased. On the other hand, herpes virus-specific thymidine kinase and of DNA-polymerases isolated from Escherichia coli, Plectonema boryanum, and herpes virus type 1 infected murine brain tissue retained their activity after incubation with AB-4 or AB-2. The compounds investigated, in view of their effect on virus reproduction, are thought to be prospective as antiviral agents.

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