Signal transmission via G protein-coupled receptors in the light of rhodopsin structure determination. | Zendy

Jerzy Ciarkowski | Zendy; Piotr Drabik | Zendy; Artur Giełdoń | Zendy; Rajmund Kaźmierkiewicz | Zendy; Rafał Ślusarz | Zendy

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Signal transmission via G protein-coupled receptors in the light of rhodopsin structure determination.

Author(s) -

Jerzy Ciarkowski,

Piotr Drabik,

Artur Giełdoń,

Rajmund Kaźmierkiewicz,

Rafał Ślusarz

Publication year - 2001

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2001_3892

Subject(s) - g protein coupled receptor , heterotrimeric g protein , rhodopsin , g protein , receptor , chemistry , signal transduction , biophysics , microbiology and biotechnology , computational biology , biology , biochemistry , retinal

G protein-coupled receptors (GPCRs) transducing diverse external signals to cells via activation of heterotrimeric GTP-binding (G) proteins, estimated to mediate actions of 60% of drugs, had been resistant to structure determination until summer 2000. The first atomic-resolution experimental structure of a GPCR, that of dark (inactive) rhodopsin, thus provides a trustworthy 3D prototype for antagonist-bound forms of this huge family of proteins. In this work, our former theoretical GPCR models are evaluated against the new experimental template. Subsequently, a working hypothesis regarding the signal transduction mechanism by GPCRs is presented.

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