Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I. | Zendy

Paweł Zubrzak | Zendy; Karol Kociolek | Zendy; Marek Smoluch | Zendy; Jerzy Silberring | Zendy; Marek L. Kowalski | Zendy; B. Szkudlińska | Zendy; Janusz Zabrocki | Zendy

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Search for new synthetic immunosuppressants II. Tetrazole analogues of hymenistatin I.

Author(s) -

Paweł Zubrzak,

Karol Kociolek,

Marek Smoluch,

Jerzy Silberring,

Marek L. Kowalski,

B. Szkudlińska,

Janusz Zabrocki

Publication year - 2001

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2001_3882

Subject(s) - tetrazole , dipeptide , reagent , chemistry , peptide , stereochemistry , combinatorial chemistry , biochemistry , organic chemistry

Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3 Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile2-psi[CN4]-Ala3', Pro3-psi[CN4]-Ala4 and Val6-psi[CN4]-Ala7 were synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocyte proliferation test (LPT).

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