Design, synthesis and biological evaluation of a new bridged immunosuppressor. | Zendy

Zbigniew Szewczuk | Zendy; Andrzej Wilczyński | Zendy; Inga Petry | Zendy; I. Z. Siemion | Zendy; Z Wieczorek | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Design, synthesis and biological evaluation of a new bridged immunosuppressor.

Author(s) -

Zbigniew Szewczuk,

Andrzej Wilczyński,

Inga Petry,

I. Z. Siemion,

Z Wieczorek

Publication year - 2001

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2001_3881

Subject(s) - epitope , peptide , immune system , chemistry , peptide sequence , molecule , sequence (biology) , human leukocyte antigen , amino acid , biochemistry , stereochemistry , antigen , microbiology and biotechnology , biology , immunology , gene , organic chemistry

A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-gamma-Abu-Asn-Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was designed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral immune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research