Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme). | Zendy

B Kotoński | Zendy; Jacek Wilczek | Zendy; Jan P. Madej | Zendy; A Zarzycki | Zendy; J Hutny | Zendy

Open Access

Activity of glycogen depolymerizing enzymes in extracts from brain tumor tissue (anaplastic astrocytoma and glioblastoma multiforme).

Author(s) -

B Kotoński,

Jacek Wilczek,

Jan P. Madej,

A Zarzycki,

J Hutny

Publication year - 2001

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2001_3869

Subject(s) - anaplastic astrocytoma , glioblastoma , astrocytoma , enzyme , glycogen phosphorylase , glycogen , chemistry , brain tumor , brain tissue , isozyme , biochemistry , cancer research , pathology , biology , medicine

An approximately threefold increase in glycogenolytic activity of the neutral alpha-1,4-glucosidase and a twofold increase in the same activity of the acid isoform have been found in extracts of anaplastic astrocytoma and glioblastoma multiforme tumors of brain tissue. "Maltase activity" of the respective enzymes increased by 60-80% in both kinds of tumor extracts. However a significant decrease in a-amylase and almost complete disappearance of phosphorylase activities have also been found in both kinds of tumors.

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