Anaerobic growth of Saccharomyces cerevisiae alleviates the lethal effect of phosphotyrosyl phosphatase activators depletion. | Zendy

B Rempoła | Zendy; Aneta Kaniak | Zendy; J.-P. di Rago | Zendy; Joanna Rytka | Zendy

Open Access

Anaerobic growth of Saccharomyces cerevisiae alleviates the lethal effect of phosphotyrosyl phosphatase activators depletion.

Author(s) -

B Rempoła,

Aneta Kaniak,

J.-P. di Rago,

Joanna Rytka

Publication year - 2001

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2001_3865

Subject(s) - saccharomyces cerevisiae , synthetic lethality , phosphatase , osmotic concentration , activator (genetics) , biochemistry , chemistry , mitochondrion , heme , gene , biology , enzyme , mutant

Saccharomyces cerevisiae homologues of phosphotyrosyl phosphatase activator (PTPA) are encoded byRRD1 and RRD2, genes whose combined deletion is synthetic lethal. Previously we have shown that the lethality of rrd1,2delta can be suppressed by increasing the osmolarity of the medium. Here we show that the lethality of rrd1,2delta is also suppressed under oxygen-limited conditions. The absence of respiration per se is not responsible for the suppression since elimination of the mitochondrial genome or a block in heme biosynthesis fail to rescue the rrd1,2delta double mutation.

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