Alzheimer's disease: its origin at the membrane, evidence and questions. | Zendy

René Buchet | Zendy; Sławomir Pikuła | Zendy

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Alzheimer's disease: its origin at the membrane, evidence and questions.

Author(s) -

René Buchet,

Sławomir Pikuła

Publication year - 2000

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2000_3991

Subject(s) - glycerophospholipid , senile plaques , chemistry , extracellular , membrane , biochemistry , amyloid (mycology) , neurodegeneration , membrane lipids , proteolysis , microbiology and biotechnology , biophysics , alzheimer's disease , biology , phospholipid , disease , pathology , enzyme , medicine , inorganic chemistry

Numerous results on membrane lipid composition from different regions of autopsied Alzheimer's disease brains in comparison with corresponding fractions isolated from control brains revealed significant differences in serine- and ethanolamine-containing glycerophospholipid as well as in glycosphingolipid content. Changes in membrane lipid composition are frequently accompanied by alterations in membrane fluidity, hydrophobic mismatch, lipid signaling pathways, transient formation and disappearance of lipid microdomains, changes in membrane permeability to cations and variations of other membrane properties. In this review we focus on possible implications of altered membrane composition on beta-amyloid precursor protein (APP) and on proteolysis of APP leading eventually to the formation of neurotoxic beta-amyloid (A beta) peptides, the major proteinaceous component of extracellular senile plaques, directly involved in Alzheimer's disease pathogenesis.

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