Open AccessMitochondrial potassium and chloride channels.
Author(s) -
Anna Kicińska,
G D bska,
Wolfram S. Kunz,
Adam Szewczyk
Publication year - 2000
Publication title -
acta biochimica polonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.452
H-Index - 78
eISSN - 1734-154X
pISSN - 0001-527X
DOI - 10.18388/abp.2000_3977
Subject(s) - potassium , potassium channel , mitochondrion , chemistry , chloride channel , chloride , membrane potential , inner mitochondrial membrane , biophysics , biochemistry , microbiology and biotechnology , biology , organic chemistry
Channels selective for potassium or chloride ions are present in inner mitochondrial membranes. They probably play an important role in mitochondrial events such as the formation of delta pH and regulation of mitochondrial volume changes. Mitochondrial potassium and chloride channels could also be the targets for pharmacologically active compounds such as potassium channel openers and antidiabetic sulfonylureas. This review describes the properties, pharmacology, and current observations concerning the functional role of mitochondrial potassium and chloride channels.
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