Structure and biosynthesis of human salivary mucins. | Zendy

Anna Zalewska | Zendy; Krzysztof Zwierz | Zendy; K Zółkowski | Zendy; A Gindzieński | Zendy

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Structure and biosynthesis of human salivary mucins.

Author(s) -

Anna Zalewska,

Krzysztof Zwierz,

K Zółkowski,

A Gindzieński

Publication year - 2000

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.2000_3960

Subject(s) - mucin , molecular mass , monomer , chemistry , biosynthesis , biochemistry , tandem repeat , glycosylation , serous fluid , glycoprotein , disulfide bond , secretion , microbiology and biotechnology , biology , gene , enzyme , organic chemistry , genome , polymer

Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa. Monomers of MG1 and MG2 contain heavily O-glycosylated tandem repeats located at the central domain of the molecules. MG1 monomers are linked by disulfide bonds located at sparsely glycosylated N- and C-end. MG1 are synthesized by mucous cells and MG2 by the serous cells of human salivary glands.

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