Hyaluronidase in human somatic tissues and urine: polymorphism and the activity in diseases. | Zendy

Berta FiszerSzafarz | Zendy; Patrick Vannier | Zendy; Anna Lityń́ska | Zendy; Liming Zou | Zendy; Barbara Czartoryska | Zendy; Anna TylkiSzymańska | Zendy

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Hyaluronidase in human somatic tissues and urine: polymorphism and the activity in diseases.

Author(s) -

Berta FiszerSzafarz,

Patrick Vannier,

Anna Lityń́ska,

Liming Zou,

Barbara Czartoryska,

Anna TylkiSzymańska

Publication year - 1995

Publication title -

acta biochimica polonica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.452

H-Index - 78

eISSN - 1734-154X

pISSN - 0001-527X

DOI - 10.18388/abp.1995_4663

Subject(s) - hyaluronidase , sialic acid , hyaluronic acid , synovial fluid , urine , endocrinology , medicine , gene isoform , chemistry , biology , enzyme , biochemistry , pathology , osteoarthritis , gene , genetics , alternative medicine

The polymorphism of hyaluronidase (EC 3.2.1.35) (Hyase) was studied on a hyaluronan-polyacrylamide gel. Liver, placenta, ovary and breast tissue were found to have 7 active isoforms while leukocytes and platelets 5 and fibroblasts displayed no hyaluronidase activity. In serum, synovial fluid and urine soluble the most acidic forms are present. Desialylation showed that most of the hyaluronidase isoforms differ in the content of sialic acid. In patients with rheumatoid arthritis, hyaluronidase activity in the synovial fluid varied from not detectable to very high. A partial deficiency was demonstrated in sera from some patients with dysostosis multiplex without mucopolysacchariduria. In I-cell disease, hyaluronidase activity in serum was as that in controls.

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